TMC1

Across TCGA cell cohorts, TMC1 mutation is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC1-associated genes across cancer lineages are TSHB, OR9A2, and SLC32A1. Each is linked with TMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC1-to-partner and partner-to-TMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by TMC1-low versus TMC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC1→partner) and Y-score (partner→TMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TSHB →	+0.084	+4.977	<.001	.002	3	2
SOFT_TISSUE	OR9A2 →	+0.028	+4.417	<.001	.004	3	1
BLOOD_Leukemia	SLC32A1 →	+0.581	+3.901	<.001	.006	3	1
BLOOD_Leukemia	MYL7 →	+0.097	+4.339	<.001	.002	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

TSHB by TMC1 expression — SOFT_TISSUE

Explore this box plot interactively →