TMC1

Across TCGA patient cohorts, TMC1 mutation is significantly associated with the RNA expression of many other genes, with 1,685 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC1-associated genes across cancer lineages are LINC01957, IMMP1LP2, and OR7E149P. Each is linked with TMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC1-to-partner and partner-to-TMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01957 grouped by TMC1-low versus TMC1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC1→partner) and Y-score (partner→TMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC01957 →	+0.041	+5.023	<.001	.003	3	3
COAD	IMMP1LP2 →	+0.232	+4.081	<.001	.004	3	2
LUAD	OR7E149P →	+0.105	+4.198	<.001	.003	3	2
LUAD	NKX2-6 →	+0.459	+4.198	<.001	.003	3	2
LUAD	GAGE2A →	+1.532	+4.841	<.001	<.001	3	2
LUAD	RNU6-23P →	+0.236	+4.612	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,685 associations by consensus.

LINC01957 by TMC1 expression — HNSC

Explore this box plot interactively →