Q-omics provides the consensus-scored RNU6-23P profile across patient tissues and cancer cell-line models. RNU6-23P expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RNU6-23P is differentially expressed in 1, with the highest sampling consensus in THCA. Additionally, RNU6-23P RNA expression shows 6,184 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight KIRC, THCA, and STAD as cancer lineages where RNU6-23P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-23P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-23P survival associations across molecular data types. RNU6-23P RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-23P RNA expression–survival associations across cancer types. High RNU6-23P expression shows unfavorable associations in KIRC, UVM, SKCM, DLBC, THCA and PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .006). Together, the overview and detailed table identify KIRC as the clearest survival context for RNU6-23P RNA expression.
This table summarizes RNU6-23P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-23P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-23P shows lower tumor expression in THCA. The THCA box plot shows higher RNU6-23P RNA expression in normal versus tumor tissue (log2 FC = −0.147, t-test p = .018).
This table shows molecular features associated with RNU6-23P in patient tissues and cancer cell lines. In patient samples, RNU6-23P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
