TMC1

Across TCGA cell cohorts, TMC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,328 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMC1-associated GO terms across cancer lineages are Hormone-mediated signaling pathway, Positive regulation of striated muscle contraction, and Regulation of fat cell differentiation. Each is linked with TMC1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMC1-to-partner and partner-to-TMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hormone-mediated signaling pathway grouped by TMC1-low versus TMC1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC1→partner) and Y-score (partner→TMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Hormone-mediated signaling pathway →	+0.051	+0.689	<.001	.004	3	8
OESOPHAGUS	Positive regulation of striated muscle contraction →	-0.223	-0.799	.001	.002	3	8
SKIN	Regulation of fat cell differentiation →	+0.041	+0.281	.001	.001	3	8
OVARY	3'-UTR-mediated mRNA stabilization →	+0.091	+0.356	<.001	.003	3	8
BLOOD_Lymphoma	Negative regulation of response to endoplasmic reticulum stress →	+0.056	+0.357	<.001	.005	3	8
OVARY	Regulation of blood-brain barrier permeability →	+0.284	+0.594	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,328 associations by consensus.

Hormone-mediated signaling pathway by TMC1 expression — PANCREAS

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