TMC1

Across TCGA patient cohorts, TMC1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC1-associated genes across cancer lineages are FoxM1, Cyclin-B1, and ATM. Each is linked with TMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC1-to-partner and partner-to-TMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TMC1-low versus TMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC1→partner) and Y-score (partner→TMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.224	+1.817	.009	.015	3	3
UCEC	Cyclin-B1 →	+0.491	+1.584	.009	.009	3	3
UCEC	ATM →	-0.376	-2.000	.013	.009	3	2
SKCM	p70-S6K →	+0.248	+2.321	.037	.035	3	1
SKCM	Rb_pS807_S811 →	+0.588	+3.459	.006	.005	3	1
SKCM	XBP1 →	-0.257	-2.321	.035	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FoxM1 by TMC1 expression — UCEC

Explore this box plot interactively →