threonine synthase like 2Genealiases: SOFAT · THS2 · TSH2
Q-omics provides the consensus-scored THNSL2 profile across patient tissues and cancer cell-line models. THNSL2 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, THNSL2 is differentially expressed in 5, with the highest sampling consensus in KICH. Additionally, THNSL2 RNA expression shows 13,638 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRP, KICH, and THYM as cancer lineages where THNSL2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for THNSL2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes THNSL2 survival associations across molecular data types. THNSL2 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible THNSL2 RNA expression–survival associations across cancer types. High THNSL2 expression shows unfavorable associations in LGG, but favorable associations in KIRP, UVM, KIRC, LUAD and MESO. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for THNSL2 RNA expression.
This table summarizes THNSL2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5, while mass-spec protein shows differences in 5. The strongest signals are observed in KICH for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for THNSL2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. THNSL2 shows lower tumor expression in KICH and UCEC and higher tumor expression in CHOL, LUAD and KIRC. The KICH box plot shows higher THNSL2 RNA expression in normal versus tumor tissue (log2 FC = −2.725, t-test p < 0.001).
This table shows molecular features associated with THNSL2 in patient tissues and cancer cell lines. In patient samples, THNSL2 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, THNSL2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BONE.
