THNSL2

Across TCGA cell cohorts, THNSL2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THNSL2-associated genes across cancer lineages are FAM181A, ARGFX, and OR2W1. Each is linked with THNSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THNSL2-to-partner and partner-to-THNSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM181A grouped by THNSL2-low versus THNSL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THNSL2→partner) and Y-score (partner→THNSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM181A →	+0.067	+5.266	<.001	.001	3	2
LUNG_NSCLC_LUAD	ARGFX →	+0.014	+4.662	.002	.005	3	1
LUNG_NSCLC_LUAD	OR2W1 →	+0.021	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF11 →	+0.004	+4.662	<.001	.005	3	1
SKIN	SIGLEC11 →	+0.020	+4.273	<.001	.006	3	1
SKIN	SERPINB11 →	+0.186	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FAM181A by THNSL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →