Q-omics provides the consensus-scored THAP5 profile across patient tissues and cancer cell-line models. THAP5 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, THAP5 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, THAP5 RNA expression shows 20,662 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where THAP5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for THAP5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes THAP5 survival associations across molecular data types. THAP5 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible THAP5 RNA expression–survival associations across cancer types. High THAP5 expression shows unfavorable associations in KICH, SCLC and UVM, but favorable associations in KIRC, LUAD and ACC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for THAP5 RNA expression.
This table summarizes THAP5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for THAP5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. THAP5 shows lower tumor expression in THCA and UCEC and higher tumor expression in HNSC, LIHC, CHOL and BRCA. The HNSC box plot shows higher THAP5 RNA expression in tumor versus normal tissue (log2 FC = +0.895, t-test p < 0.001).
This table shows molecular features associated with THAP5 in patient tissues and cancer cell lines. In patient samples, THAP5 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, THAP5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BLOOD_Leukemia.
