THAP5

Across TCGA patient cohorts, THAP5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP5-associated genes across cancer lineages are C-Raf, JNK2, and Notch1. Each is linked with THAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP5-to-partner and partner-to-THAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by THAP5-low versus THAP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP5→partner) and Y-score (partner→THAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.170	+3.321	.006	.010	3	2
UCEC	JNK2 →	+0.220	+2.115	.011	.019	3	1
UCEC	Notch1 →	+0.221	+2.807	<.001	.003	3	1
UCEC	PCNA →	+0.318	+3.906	<.001	<.001	3	1
UCEC	PDCD4 →	-0.602	-3.169	.003	.018	3	1
UCEC	Rab25 →	-0.445	-2.321	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

C-Raf by THAP5 expression — UCEC

Explore this box plot interactively →