THAP5

Across TCGA cell cohorts, THAP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,335 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THAP5-associated GO terms across cancer lineages are Positive regulation of DNA recombination, DNA synthesis involved in DNA replication, and Translesion synthesis. Each is linked with THAP5 in more than 13 cancer types. Because this analysis shows association rather than direction, both THAP5-to-partner and partner-to-THAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA recombination grouped by THAP5-low versus THAP5-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP5→partner) and Y-score (partner→THAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of DNA recombination →	+0.074	+0.826	<.001	<.001	3	14
LUNG_SCLC	DNA synthesis involved in DNA replication →	+0.088	+0.506	<.001	<.001	3	14
LUNG_SCLC	Translesion synthesis →	+0.107	+0.892	<.001	<.001	3	14
BREAST	DNA biosynthetic process →	+0.065	+0.752	<.001	<.001	3	13
SOFT_TISSUE	Regulation of telomeric D-loop disassembly →	+0.116	+0.949	<.001	<.001	3	13
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.068	+0.862	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,335 associations by consensus.

Positive regulation of DNA recombination by THAP5 expression — LARGE_INTESTINE

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