THAP5

Across TCGA cell cohorts, THAP5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THAP5-associated genes across cancer lineages are TECRL, OR5V1, and ZPBP. Each is linked with THAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP5-to-partner and partner-to-THAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECRL grouped by THAP5-low versus THAP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP5→partner) and Y-score (partner→THAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ZPBP →	+0.059	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GCGR →	+0.129	+3.584	.007	.006	2	1
LARGE_INTESTINE	GAS2L2 →	+0.092	+3.807	.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TECRL by THAP5 expression — LARGE_INTESTINE

Explore this box plot interactively →