Q-omics provides the consensus-scored TAMM41 profile across patient tissues and cancer cell-line models. TAMM41 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TAMM41 is differentially expressed in 12, with the highest sampling consensus in COAD. Additionally, TAMM41 RNA expression shows 20,857 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, COAD, and ACC as cancer lineages where TAMM41 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TAMM41 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TAMM41 survival associations across molecular data types. TAMM41 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (4) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TAMM41 RNA expression–survival associations across cancer types. High TAMM41 expression shows unfavorable associations in KIRC, KICH, MESO, ACC and LIHC, but favorable associations in READ. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TAMM41 RNA expression.
This table summarizes TAMM41 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in COAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TAMM41. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TAMM41 shows lower tumor expression in THCA and KIRC and higher tumor expression in COAD, LIHC, STAD and CHOL. The COAD box plot shows higher TAMM41 RNA expression in tumor versus normal tissue (log2 FC = +0.964, t-test p < 0.001).
This table shows molecular features associated with TAMM41 in patient tissues and cancer cell lines. In patient samples, TAMM41 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TAMM41 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
