TAMM41

Across TCGA patient cohorts, TAMM41 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAMM41-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and GAPDH. Each is linked with TAMM41 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAMM41-to-partner and partner-to-TAMM41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TAMM41-low versus TAMM41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAMM41→partner) and Y-score (partner→TAMM41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-3.584	.001	.002	3	1
UCEC	A-Raf_pS299 →	-0.100	-2.115	.025	.017	3	1
UCEC	GAPDH →	+0.487	+2.459	.015	.018	3	1
UCEC	JNK2 →	+0.231	+1.765	.001	.014	3	1
UCEC	Ku80 →	+0.203	+1.778	.022	.008	3	1
UCEC	NF-kB-p65_pS536 →	-0.355	-2.999	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by TAMM41 expression — UCEC

Explore this box plot interactively →