Q-omics provides the consensus-scored SPINK14 profile across patient tissues and cancer cell-line models. SPINK14 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, SPINK14 is differentially expressed in 6, with the highest sampling consensus in LUSC. Additionally, SPINK14 RNA expression shows 14,437 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight BLCA, LUSC, and LSCC as cancer lineages where SPINK14 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPINK14 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPINK14 survival associations across molecular data types. SPINK14 RNA expression shows survival associations in the most cancer types (17), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPINK14 RNA expression–survival associations across cancer types. High SPINK14 expression shows unfavorable associations in LIHC, LUSC, TGCT, LAML and SKCM, but favorable associations in BLCA. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for SPINK14 RNA expression.
This table summarizes SPINK14 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for SPINK14. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPINK14 shows lower tumor expression in LUSC and HNSC and higher tumor expression in LIHC, UCEC, THCA and PRAD. The LUSC box plot shows higher SPINK14 RNA expression in normal versus tumor tissue (log2 FC = −0.616, t-test p < 0.001).
This table shows molecular features associated with SPINK14 in patient tissues and cancer cell lines. In patient samples, SPINK14 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SPINK14 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
