Across TCGA patient cohorts, SPINK14 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK14-associated genes across cancer lineages are SSTR5, RNU4-13P, and RNU6-558P. Each is linked with SPINK14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK14-to-partner and partner-to-SPINK14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK14→partner) and Y-score (partner→SPINK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SSTR5 →	+1.087	+3.608	<.001	.009	3	1
UCEC	RNU4-13P →	+0.258	+5.049	<.001	.002	3	1
UCEC	RNU6-558P →	+0.833	+3.830	.005	.005	3	1
UCEC	RNA5SP129 →	+0.549	+3.354	.006	.007	3	1
UCEC	MRPS18BP1 →	+0.282	+4.877	<.001	.003	3	1
UCEC	LINC01811 →	+0.627	+3.754	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SPINK14 survival (RNA) · tumor vs normal (RNA) · all SPINK14 data types