Across TCGA pan-cancer cohorts, SPINK14 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPINK14 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SPINK14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPINK14 expression acts as an unfavorable survival marker.

LUSC are the cancer types where SPINK14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.086	0.776	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SPINK14 tumor-vs-normal RNA expression · all SPINK14 data types