spindlin family member 3Genealiases: SPIN-3 · TDRD27 · bA445O16.1
Q-omics provides the consensus-scored SPIN3 profile across patient tissues and cancer cell-line models. SPIN3 expression is associated with patient survival in 29 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, SPIN3 is differentially expressed in 8, with the highest sampling consensus in COAD. Additionally, SPIN3 RNA expression shows 20,422 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight COAD, and KIRP as cancer lineages where SPIN3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPIN3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPIN3 survival associations across molecular data types. SPIN3 RNA expression shows survival associations in the most cancer types (29). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPIN3 RNA expression–survival associations across cancer types. High SPIN3 expression shows unfavorable associations in COAD, UCEC, LIHC and KICH, but favorable associations in READ and MESO. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for SPIN3 RNA expression.
This table summarizes SPIN3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in LIHC for RNA.
This table ranks reproducible tumor–normal expression differences for SPIN3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPIN3 shows lower tumor expression in THCA and KICH and higher tumor expression in COAD, LIHC, CHOL and READ. The COAD box plot shows higher SPIN3 RNA expression in tumor versus normal tissue (log2 FC = +0.895, t-test p < 0.001).
This table shows molecular features associated with SPIN3 in patient tissues and cancer cell lines. In patient samples, SPIN3 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, SPIN3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and SOFT_TISSUE.
