Across TCGA patient cohorts, SPIN3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIN3-associated genes across cancer lineages are EGFR_pY1068, Gab2, and Heregulin. Each is linked with SPIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIN3-to-partner and partner-to-SPIN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIN3→partner) and Y-score (partner→SPIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.000	.020	.030	3	1
UCEC	Gab2 →	+0.462	+2.584	.002	.010	3	1
UCEC	Heregulin →	-0.151	-2.986	.003	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.209	.008	.011	3	1
UCEC	MEK1 →	+0.352	+2.222	.023	.011	3	1
UCEC	Notch1 →	+0.167	+1.700	.005	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

SPIN3 survival (RNA) · tumor vs normal (RNA) · all SPIN3 data types