sosondowah ankyrin repeat domain family member CGenealiases: ANKRD57 · C2orf26
Q-omics provides the consensus-scored SOWAHC profile across patient tissues and cancer cell-line models. SOWAHC expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SOWAHC is differentially expressed in 13, with the highest sampling consensus in KICH. Additionally, SOWAHC RNA expression shows 19,797 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, KICH, and UVM as cancer lineages where SOWAHC shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SOWAHC — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SOWAHC survival associations across molecular data types. SOWAHC RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SOWAHC RNA expression–survival associations across cancer types. High SOWAHC expression shows unfavorable associations in LUAD, UVM, PAAD, UCEC and LGG, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SOWAHC RNA expression.
This table summarizes SOWAHC tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 6. The strongest signals are observed in KICH for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for SOWAHC. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SOWAHC shows lower tumor expression in KICH, THCA, KIRC, KIRP and UCEC and higher tumor expression in LUSC. The KICH box plot shows higher SOWAHC RNA expression in normal versus tumor tissue (log2 FC = −2.201, t-test p < 0.001).
This table shows molecular features associated with SOWAHC in patient tissues and cancer cell lines. In patient samples, SOWAHC shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, SOWAHC RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
