Across TCGA patient cohorts, SOWAHC mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOWAHC-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and EGFR_pY1068. Each is linked with SOWAHC in more than 1 cancer types. Because this analysis shows association rather than direction, both SOWAHC-to-partner and partner-to-SOWAHC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOWAHC→partner) and Y-score (partner→SOWAHC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+2.087	.020	.005	3	2
UCEC	14-3-3_beta →	-0.108	-2.558	.005	.010	3	1
UCEC	EGFR_pY1068 →	-0.338	-4.321	<.001	<.001	3	1
UCEC	EGFR →	-0.156	-2.321	.011	.034	3	1
UCEC	A-Raf_pS299 →	-0.168	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.204	+2.087	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

SOWAHC survival (RNA) · tumor vs normal (RNA) · all SOWAHC data types