solute carrier organic anion transporter family member 2B1Genealiases: OATP-B · OATP2B1 · OATPB · SLC21A9
Q-omics provides the consensus-scored SLCO2B1 profile across patient tissues and cancer cell-line models. SLCO2B1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, SLCO2B1 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, SLCO2B1 protein abundance shows 28,812 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, KIRC, and LSCC as cancer lineages where SLCO2B1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SLCO2B1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SLCO2B1 survival associations across molecular data types. SLCO2B1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SLCO2B1 RNA expression–survival associations across cancer types. High SLCO2B1 expression shows unfavorable associations in STAD and LUSC, but favorable associations in SKCM, HNSC, SCLC and LUAD. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for SLCO2B1 RNA expression.
This table summarizes SLCO2B1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SLCO2B1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SLCO2B1 shows lower tumor expression in LUAD, LUSC, UCEC and LIHC and higher tumor expression in KIRC and STAD. The KIRC box plot shows higher SLCO2B1 RNA expression in tumor versus normal tissue (log2 FC = +2.000, t-test p < 0.001).
This table shows molecular features associated with SLCO2B1 in patient tissues and cancer cell lines. In patient samples, SLCO2B1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SLCO2B1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and LARGE_INTESTINE.
