SLCO2B1

Across TCGA patient cohorts, SLCO2B1 mutation is significantly associated with the RNA expression of many other genes, with 3,847 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO2B1-associated genes across cancer lineages are BAG3, MED27, and METTL3. Each is linked with SLCO2B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO2B1-to-partner and partner-to-SLCO2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by SLCO2B1-low versus SLCO2B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO2B1→partner) and Y-score (partner→SLCO2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.583	+2.099	<.001	<.001	3	3
UCEC	MED27 →	+0.348	+2.991	<.001	<.001	3	3
UCEC	METTL3 →	+0.317	+2.136	.006	.002	3	3
UCEC	METTL2A →	+0.415	+2.110	<.001	<.001	3	3
SKCM	PTAR1 →	+0.595	+1.629	.003	.005	3	3
BLCA	RNU6-618P →	+0.321	+4.685	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,847 associations by consensus.

BAG3 by SLCO2B1 expression — UCEC

Explore this box plot interactively →