SLCO2B1

Across TCGA cell cohorts, SLCO2B1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO2B1-associated genes across cancer lineages are HRG, KAAG1, and FERD3L. Each is linked with SLCO2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLCO2B1-to-partner and partner-to-SLCO2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRG grouped by SLCO2B1-low versus SLCO2B1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO2B1→partner) and Y-score (partner→SLCO2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HRG →	+0.402	+3.855	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.082	+3.855	<.001	.007	3	1
BLOOD_Leukemia	FERD3L →	+0.018	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DCLK3 →	+0.159	+3.769	.004	.008	3	1
BLOOD_Leukemia	TMEM244 →	+0.271	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.008	+3.551	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

HRG by SLCO2B1 expression — BLOOD_Leukemia

Explore this box plot interactively →