SLCO2B1

Across TCGA cell cohorts, SLCO2B1 mutation is significantly associated with the mutation status of many other genes, with 2,344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLCO2B1-associated genes across cancer lineages are WRN, SNPH, and RPGRIP1L. Each is linked with SLCO2B1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLCO2B1-to-partner and partner-to-SLCO2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WRN grouped by SLCO2B1-low versus SLCO2B1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO2B1→partner) and Y-score (partner→SLCO2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WRN →	+3.339	+4.662	.003	.003	1	4
BLOOD_Leukemia	SNPH →	+3.700	+4.498	<.001	<.001	1	3
BLOOD_Leukemia	RPGRIP1L →	+2.870	+3.347	.009	.009	1	3
BLOOD_Leukemia	SCN4A →	+2.963	+3.960	.001	.001	1	3
LUNG_SCLC	TNR →	+2.137	+3.781	.008	.008	1	3
LUNG_SCLC	PCNX2 →	+3.307	+3.777	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,344 associations by consensus.

WRN by SLCO2B1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →