SLCO2B1

Across TCGA patient cohorts, SLCO2B1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLCO2B1-associated genes across cancer lineages are MEK1, Shc_pY317, and ATM. Each is linked with SLCO2B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLCO2B1-to-partner and partner-to-SLCO2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLCO2B1-low versus SLCO2B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLCO2B1→partner) and Y-score (partner→SLCO2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.357	+2.906	.002	.001	3	3
UCEC	Shc_pY317 →	-0.191	-2.058	<.001	<.001	3	3
UCEC	ATM →	-0.499	-2.058	<.001	<.001	3	3
COAD	GAPDH →	+0.886	+2.815	.001	.036	3	3
LUAD	YB-1_pS102 →	+0.244	+2.824	.029	.036	3	2
UCEC	ERK2 →	+0.186	+1.925	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

MEK1 by SLCO2B1 expression — UCEC

Explore this box plot interactively →