siah E3 ubiquitin protein ligase family member 3Genealiases: []
Q-omics provides the consensus-scored SIAH3 profile across patient tissues and cancer cell-line models. SIAH3 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, SIAH3 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, SIAH3 RNA expression shows 14,691 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight HNSC, KIRC, and KIRP as cancer lineages where SIAH3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SIAH3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SIAH3 survival associations across molecular data types. SIAH3 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SIAH3 RNA expression–survival associations across cancer types. High SIAH3 expression shows unfavorable associations in UVM, but favorable associations in HNSC, PAAD, CHOL, SKCM and LUAD. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for SIAH3 RNA expression.
This table summarizes SIAH3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for SIAH3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SIAH3 shows lower tumor expression in KIRC, KIRP, HNSC, KICH, COAD and LUSC. The KIRC box plot shows higher SIAH3 RNA expression in normal versus tumor tissue (log2 FC = −1.730, t-test p < 0.001).
This table shows molecular features associated with SIAH3 in patient tissues and cancer cell lines. In patient samples, SIAH3 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, SIAH3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BONE.
