Across TCGA cell cohorts, SIAH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,504 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIAH3-associated GO terms across cancer lineages are Translational initiation, Nucleoside triphosphate metabolic process, and Spliceosomal complex assembly. Each is linked with SIAH3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SIAH3-to-partner and partner-to-SIAH3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH3→partner) and Y-score (partner→SIAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Translational initiation →	+0.067	+1.147	.001	.002	3	7
LUNG_SCLC	Nucleoside triphosphate metabolic process →	+0.077	+0.916	<.001	.007	3	6
OVARY	Spliceosomal complex assembly →	+0.066	+0.681	<.001	<.001	3	6
BONE	RNA splicing, via transesterification reactions →	+0.057	+0.959	<.001	.008	2	7
BONE	Protein-RNA complex organization →	+0.091	+1.099	<.001	.001	3	6
OVARY	Negative regulation of mRNA metabolic process →	+0.064	+0.917	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,504 associations by consensus.

Exploration

SIAH3 survival (RNA) · tumor vs normal (RNA) · all SIAH3 data types