Across TCGA patient cohorts, SIAH3 mutation is significantly associated with the RNA expression of many other genes, with 2,686 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH3-associated genes across cancer lineages are MIR4499, RN7SKP214, and RNU6-1086P. Each is linked with SIAH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIAH3-to-partner and partner-to-SIAH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH3→partner) and Y-score (partner→SIAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4499 →	+0.905	+4.990	<.001	.009	3	3
UCEC	RN7SKP214 →	+0.208	+2.334	.002	.001	3	2
HNSC	RNU6-1086P →	+0.220	+4.468	<.001	.006	3	2
BRCA	MIR4289 →	+0.321	+7.731	<.001	.009	3	2
BRCA	SNORD115-6 →	+0.278	+7.731	.002	.009	3	2
SKCM	BNIP3P2 →	+0.044	+4.421	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,686 associations by consensus.

Exploration

SIAH3 survival (RNA) · tumor vs normal (RNA) · all SIAH3 data types