Across TCGA patient cohorts, SIAH3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIAH3-associated genes across cancer lineages are PCNA, EGFR_pY1173, and eIF4E. Each is linked with SIAH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH3-to-partner and partner-to-SIAH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH3→partner) and Y-score (partner→SIAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.307	+3.169	.001	.018	3	2
UCEC	EGFR_pY1173 →	+0.082	+3.020	.023	.019	3	1
UCEC	eIF4E →	+0.225	+2.000	.017	.032	2	2
UCEC	FoxM1 →	+0.289	+2.700	.013	.006	3	1
UCEC	p62 Lck ligand →	+0.431	+2.999	.003	.035	3	1
UCEC	PDCD4 →	-0.580	-2.000	.006	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

SIAH3 survival (RNA) · tumor vs normal (RNA) · all SIAH3 data types