Across TCGA cell cohorts, SIAH3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIAH3-associated genes across cancer lineages are OR4F4 and OR6Q1. Each is linked with SIAH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIAH3-to-partner and partner-to-SIAH3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIAH3→partner) and Y-score (partner→SIAH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.021	+3.688	<.001	.002	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

SIAH3 survival (RNA) · tumor vs normal (RNA) · all SIAH3 data types