Q-omics provides the consensus-scored SHOX2 profile across patient tissues and cancer cell-line models. SHOX2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SHOX2 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, SHOX2 RNA expression shows 15,537 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRP, HNSC, and BRCA as cancer lineages where SHOX2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SHOX2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SHOX2 survival associations across molecular data types. SHOX2 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SHOX2 RNA expression–survival associations across cancer types. High SHOX2 expression shows unfavorable associations in KIRP, ACC, KIRC, MESO, BLCA and LGG. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SHOX2 RNA expression.
This table summarizes SHOX2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for SHOX2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SHOX2 shows lower tumor expression in BRCA and higher tumor expression in HNSC, LUAD, LUSC, COAD and KIRC. The HNSC box plot shows higher SHOX2 RNA expression in tumor versus normal tissue (log2 FC = +1.756, t-test p < 0.001).
This table shows molecular features associated with SHOX2 in patient tissues and cancer cell lines. In patient samples, SHOX2 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, SHOX2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BREAST.
