SHOX2

Across TCGA cell cohorts, SHOX2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SHOX2-associated genes across cancer lineages are OR4D1, KRT28, and DAOA. Each is linked with SHOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHOX2-to-partner and partner-to-SHOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D1 grouped by SHOX2-low versus SHOX2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX2→partner) and Y-score (partner→SHOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4D1 →	+0.096	+3.727	<.001	.008	3	1
LUNG_NSCLC_LUAD	KRT28 →	+0.005	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	DAOA →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	IL31 →	+0.025	+4.628	.004	.001	3	1
LUNG_NSCLC_LUAD	DNAAF6 →	+0.056	+3.693	<.001	.009	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR4D1 by SHOX2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →