SHOX2

Across TCGA pan-cancer cohorts, SHOX2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SHOX2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SHOX2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SHOX2 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where SHOX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SHOX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.756	<.001	12	view →
LUAD	All	III,IV	+1.161	<.001	9	view →
LUSC	Female	II,III,IV	+2.628	<.001	8	view →
COAD	All	II,III,IV	+0.269	<.001	8	view →
KIRC	Male	III,IV	+0.268	<.001	7	view →
BRCA	All	All	−0.361	<.001	6	view →
STAD	Male	II,III,IV	+0.307	.003	6	view →
BLCA	All	III,IV	+0.782	.009	4	view →
LIHC	Female	All	+0.098	.003	4	view →
CHOL	All	All	+0.574	<.001	2	view →
PRAD	All	All	+0.147	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SHOX2–HNSC

Open the HNSC breakdown →