SHOX2

Across TCGA patient cohorts, SHOX2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SHOX2-associated genes across cancer lineages are JNK2, Rad50, and TIGAR. Each is linked with SHOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SHOX2-to-partner and partner-to-SHOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SHOX2-low versus SHOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SHOX2→partner) and Y-score (partner→SHOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.177	+1.502	.015	.030	3	2
UCEC	Rad50 →	-0.197	-1.502	.026	.030	3	2
UCEC	TIGAR →	+0.122	+1.529	.028	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.603	+1.720	.005	.025	3	2
UCEC	Caspase-8 →	-0.227	-2.295	.014	.005	3	2
UCEC	eIF4E →	+0.184	+2.700	.017	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK2 by SHOX2 expression — UCEC

Explore this box plot interactively →