serpin family E member 2Genealiases: GDN · GDNPF · PI-7 · PI7 · PN-1 · PN1
Q-omics provides the consensus-scored SERPINE2 profile across patient tissues and cancer cell-line models. SERPINE2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, SERPINE2 is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, SERPINE2 protein abundance shows 22,287 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight BLCA, KICH, and GBM as cancer lineages where SERPINE2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SERPINE2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SERPINE2 survival associations across molecular data types. SERPINE2 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SERPINE2 RNA expression–survival associations across cancer types. High SERPINE2 expression shows unfavorable associations in BLCA, MESO, UVM, STAD and LIHC, but favorable associations in SKCM. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for SERPINE2 RNA expression.
This table summarizes SERPINE2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for SERPINE2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SERPINE2 shows lower tumor expression in KICH and higher tumor expression in KIRP, HNSC, COAD, KIRC and LUAD. The KICH box plot shows higher SERPINE2 RNA expression in normal versus tumor tissue (log2 FC = −3.361, t-test p < 0.001).
This table shows molecular features associated with SERPINE2 in patient tissues and cancer cell lines. In patient samples, SERPINE2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, SERPINE2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BREAST.
