SERPINE2

Across TCGA patient cohorts, SERPINE2 mutation is significantly associated with the RNA expression of many other genes, with 3,474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINE2-associated genes across cancer lineages are MIR3188, RALBP1P2, and RNU7-52P. Each is linked with SERPINE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINE2-to-partner and partner-to-SERPINE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3188 grouped by SERPINE2-low versus SERPINE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE2→partner) and Y-score (partner→SERPINE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3188 →	+0.775	+3.333	<.001	.001	3	3
SKCM	RALBP1P2 →	+0.080	+4.093	.003	.005	3	2
PRAD	RNU7-52P →	+0.503	+7.939	<.001	.008	3	2
UCEC	BAG3 →	+0.580	+2.662	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.403	+3.169	.004	<.001	3	2
UCEC	PPP2R2D →	+0.274	+2.158	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,474 associations by consensus.

MIR3188 by SERPINE2 expression — COAD

Explore this box plot interactively →