SERPINE2

Across TCGA pan-cancer cohorts, SERPINE2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SERPINE2 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SERPINE2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SERPINE2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, LSCC, and COAD are the cancer types where SERPINE2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	32	view →
LSCC	DFS	Tertile	All	0.301	0.928	.004	8	view →
COAD	DFS	Median	III,IV	0.826	1.000	.023	6	view →
PDAC	OS	Median	III,IV	0.547	0.336	.035	4	view →
LUAD	DFS	Quartile	II,III,IV	0.822	0.203	.032	4	view →
HNSC	OS	Median	IV	0.653	0.818	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SERPINE2–CCRCC (DFS)

Open the CCRCC breakdown →