SERPINE2

Across TCGA cell cohorts, SERPINE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,410 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SERPINE2-associated GO terms across cancer lineages are Negative regulation of plasminogen activation, Regulation of astrocyte differentiation, and Regulation of plasminogen activation. Each is linked with SERPINE2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SERPINE2-to-partner and partner-to-SERPINE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of plasminogen activation grouped by SERPINE2-low versus SERPINE2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINE2→partner) and Y-score (partner→SERPINE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of plasminogen activation →	+1.459	+2.961	<.001	<.001	3	15
URINARY_TRACT	Regulation of astrocyte differentiation →	+0.169	+2.944	<.001	<.001	3	14
LIVER	Regulation of plasminogen activation →	+0.346	+3.849	.001	<.001	3	13
PANCREAS	Negative regulation of platelet aggregation →	+0.232	+2.294	<.001	<.001	3	12
BONE	Regulation of protein maturation →	+0.231	+2.879	<.001	<.001	3	12
BONE	Regulation of protein processing →	+0.213	+2.879	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,410 associations by consensus.

Negative regulation of plasminogen activation by SERPINE2 expression — BONE

Explore this box plot interactively →