ribosomal protein L27Genealiases: DBA16 · L27 · eL27
Q-omics provides the consensus-scored RPL27 profile across patient tissues and cancer cell-line models. RPL27 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, RPL27 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, RPL27 protein abundance shows 27,016 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, KIRC, and GBM as cancer lineages where RPL27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RPL27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RPL27 survival associations across molecular data types. RPL27 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (2) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RPL27 RNA expression–survival associations across cancer types. High RPL27 expression shows unfavorable associations in ACC, LIHC, KIRP, CESC, HNSC and KICH. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for RPL27 RNA expression.
This table summarizes RPL27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for RPL27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RPL27 shows lower tumor expression in KICH and higher tumor expression in KIRC, KIRP, LIHC, COAD and HNSC. The KIRC box plot shows higher RPL27 RNA expression in tumor versus normal tissue (log2 FC = +0.736, t-test p < 0.001).
This table shows molecular features associated with RPL27 in patient tissues and cancer cell lines. In patient samples, RPL27 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, RPL27 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
