ribonuclease A family member 1, pancreaticGenealiases: RAC1 · RIB1 · RNS1
Q-omics provides the consensus-scored RNASE1 profile across patient tissues and cancer cell-line models. RNASE1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, RNASE1 is differentially expressed in 15, with the highest sampling consensus in KICH. Additionally, RNASE1 RNA expression shows 23,602 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRP, KICH, and LUAD as cancer lineages where RNASE1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNASE1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNASE1 survival associations across molecular data types. RNASE1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNASE1 RNA expression–survival associations across cancer types. High RNASE1 expression shows unfavorable associations in KIRP, COAD, BRCA and STAD, but favorable associations in KIRC and THCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .007). Together, the overview and detailed table identify KIRP as the clearest survival context for RNASE1 RNA expression.
This table summarizes RNASE1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for RNASE1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNASE1 shows lower tumor expression in KICH, KIRP, LUAD, LUSC and UCEC and higher tumor expression in LIHC. The KICH box plot shows higher RNASE1 RNA expression in normal versus tumor tissue (log2 FC = −2.703, t-test p < 0.001).
This table shows molecular features associated with RNASE1 in patient tissues and cancer cell lines. In patient samples, RNASE1 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, RNASE1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and UPPER_AERODIGESTIVE_TRACT.
