RNASE1

Across TCGA pan-cancer cohorts, RNASE1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RNASE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNASE1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNASE1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LUAD are the cancer types where RNASE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.703	<.001	11	view →
KIRP	Female	II,III,IV	−2.628	<.001	11	view →
LUAD	Male	III,IV	−2.230	<.001	11	view →
LUSC	Female	II,III,IV	−3.610	<.001	9	view →
LIHC	Female	II,III,IV	+1.599	<.001	8	view →
UCEC	All	III,IV	−1.406	<.001	6	view →
BRCA	All	III,IV	−1.117	<.001	6	view →
HNSC	Female	All	+1.055	.008	6	view →
COAD	All	All	−0.733	<.001	6	view →
BLCA	Male	III,IV	−1.844	.002	4	view →
CHOL	Female	All	+2.196	<.001	2	view →
READ	Female	All	−2.090	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RNASE1–KICH

Open the KICH breakdown →