RNASE1

Across TCGA patient cohorts, RNASE1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RNASE1-associated genes across cancer lineages are RN7SKP146, RNA5SP92, and MIR7843. Each is linked with RNASE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE1-to-partner and partner-to-RNASE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP146 grouped by RNASE1-low versus RNASE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE1→partner) and Y-score (partner→RNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP146 →	+0.155	+5.254	<.001	.001	3	2
SKCM	RNA5SP92 →	+0.304	+4.680	<.001	.007	3	2
CESC	MIR7843 →	+0.587	+5.418	<.001	.005	3	1
SKCM	OR5B2 →	+0.160	+4.470	<.001	.005	3	1
SKCM	RNA5SP349 →	+0.401	+4.970	<.001	.005	3	1
SKCM	RNY4P7 →	+0.660	+5.302	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

RN7SKP146 by RNASE1 expression — SKCM

Explore this box plot interactively →