RNASE1

Across TCGA cell cohorts, RNASE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,355 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASE1-associated GO terms across cancer lineages are T cell mediated cytotoxicity, Regulation of interleukin-13 production, and Positive regulation of protein localization to plasma membrane. Each is linked with RNASE1 in more than 7 cancer types. Because this analysis shows association rather than direction, both RNASE1-to-partner and partner-to-RNASE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T cell mediated cytotoxicity grouped by RNASE1-low versus RNASE1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE1→partner) and Y-score (partner→RNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	T cell mediated cytotoxicity →	+0.180	+2.047	<.001	<.001	3	8
PANCREAS	Regulation of interleukin-13 production →	+0.101	+3.483	.008	.001	3	7
BREAST	Positive regulation of protein localization to plasma membrane →	+0.087	+1.738	.004	.006	3	7
BREAST	Negative regulation of intrinsic apoptotic signaling pathway →	+0.080	+1.517	<.001	.006	3	7
BLOOD_Leukemia	Positive regulation of iron ion transport →	+1.166	+2.095	<.001	.001	3	7
BLOOD_Leukemia	Positive regulation of iron ion transmembrane transport →	+1.166	+2.095	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,355 associations by consensus.

T cell mediated cytotoxicity by RNASE1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →