REV1 DNA directed polymeraseGenealiases: AIBP80 · REV1L
Q-omics provides the consensus-scored REV1 profile across patient tissues and cancer cell-line models. REV1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, REV1 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, REV1 RNA expression shows 21,685 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight HNSC, THCA, and ACC as cancer lineages where REV1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for REV1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes REV1 survival associations across molecular data types. REV1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible REV1 RNA expression–survival associations across cancer types. High REV1 expression shows unfavorable associations in ACC and KIRP, but favorable associations in HNSC, KIRC, BLCA and UCS. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for REV1 RNA expression.
This table summarizes REV1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 6. The strongest signals are observed in THCA for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for REV1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. REV1 shows lower tumor expression in THCA, BRCA and KICH and higher tumor expression in LIHC, CHOL and HNSC. The THCA box plot shows higher REV1 RNA expression in normal versus tumor tissue (log2 FC = −0.824, t-test p < 0.001).
This table shows molecular features associated with REV1 in patient tissues and cancer cell lines. In patient samples, REV1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, REV1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and BLOOD_Leukemia.
