REV1

Across TCGA patient cohorts, REV1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REV1-associated genes across cancer lineages are Notch1, S6_pS240_S244, and ASNS. Each is linked with REV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both REV1-to-partner and partner-to-REV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by REV1-low versus REV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REV1→partner) and Y-score (partner→REV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.131	+1.691	.001	.011	3	2
UCEC	S6_pS240_S244 →	+0.325	+1.713	.006	.024	3	2
UCEC	ASNS →	+0.360	+1.716	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.601	+1.756	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.524	+2.502	.001	.001	3	2
UCEC	eIF4E →	+0.132	+1.637	.033	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Notch1 by REV1 expression — UCEC

Explore this box plot interactively →