ring finger and CHY zinc finger domain containing 1Genealiases: ARNIP · CHIMP · PIRH2 · PRO1996 · RNF199 · ZCHY
Q-omics provides the consensus-scored RCHY1 profile across patient tissues and cancer cell-line models. RCHY1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RCHY1 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, RCHY1 RNA expression shows 20,191 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, THCA, and ACC as cancer lineages where RCHY1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RCHY1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RCHY1 survival associations across molecular data types. RCHY1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (6) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RCHY1 RNA expression–survival associations across cancer types. High RCHY1 expression shows unfavorable associations in CESC and LIHC, but favorable associations in KIRC, MESO, READ and PAAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for RCHY1 RNA expression.
This table summarizes RCHY1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 3. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for RCHY1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RCHY1 shows lower tumor expression in THCA, LUSC, LUAD, KIRP and HNSC and higher tumor expression in CHOL. The THCA box plot shows higher RCHY1 RNA expression in normal versus tumor tissue (log2 FC = −0.938, t-test p < 0.001).
This table shows molecular features associated with RCHY1 in patient tissues and cancer cell lines. In patient samples, RCHY1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, RCHY1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and LARGE_INTESTINE.
