RCHY1

Across TCGA patient cohorts, RCHY1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RCHY1-associated genes across cancer lineages are FoxM1, EGFR_pY1068, and EGFR. Each is linked with RCHY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RCHY1-to-partner and partner-to-RCHY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RCHY1-low versus RCHY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RCHY1→partner) and Y-score (partner→RCHY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.286	+3.459	.028	.005	3	2
UCEC	EGFR_pY1068 →	-0.266	-2.321	.035	.035	3	1
UCEC	EGFR →	-0.223	-2.321	.005	.035	3	1
UCEC	MEK1 →	+0.397	+2.321	.030	.035	3	1
UCEC	MSH2 →	-0.279	-2.973	.016	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.251	+2.335	.015	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FoxM1 by RCHY1 expression — UCEC

Explore this box plot interactively →