RAB40C, member RAS oncogene familyGenealiases: RARL · RASL8C
Q-omics provides the consensus-scored RAB40C profile across patient tissues and cancer cell-line models. RAB40C expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, RAB40C is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, RAB40C RNA expression shows 19,232 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and KIRC as cancer lineages where RAB40C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RAB40C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RAB40C survival associations across molecular data types. RAB40C RNA expression shows survival associations in the most cancer types (17), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RAB40C RNA expression–survival associations across cancer types. High RAB40C expression shows unfavorable associations in ACC, LIHC, MESO, KIRP and THCA, but favorable associations in HNSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for RAB40C RNA expression.
This table summarizes RAB40C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for RAB40C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RAB40C shows higher tumor expression in KIRC, LIHC, HNSC, COAD, BRCA and STAD. The KIRC box plot shows higher RAB40C RNA expression in tumor versus normal tissue (log2 FC = +0.862, t-test p < 0.001).
This table shows molecular features associated with RAB40C in patient tissues and cancer cell lines. In patient samples, RAB40C shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, RAB40C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BREAST.
