POU class 4 homeobox 3Genealiases: BRN3C · DFNA15 · DFNA42 · DFNA52
Q-omics provides the consensus-scored POU4F3 profile across patient tissues and cancer cell-line models. POU4F3 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, POU4F3 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, POU4F3 RNA expression shows 14,971 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UCEC, THCA, and THYM as cancer lineages where POU4F3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for POU4F3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes POU4F3 survival associations across molecular data types. POU4F3 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible POU4F3 RNA expression–survival associations across cancer types. High POU4F3 expression shows unfavorable associations in UCEC, LGG, HNSC and STAD, but favorable associations in UCS and PAAD. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for POU4F3 RNA expression.
This table summarizes POU4F3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for POU4F3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. POU4F3 shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, LUAD, KICH and BRCA. The THCA box plot shows higher POU4F3 RNA expression in normal versus tumor tissue (log2 FC = −0.137, t-test p = .005).
This table shows molecular features associated with POU4F3 in patient tissues and cancer cell lines. In patient samples, POU4F3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, POU4F3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LARGE_INTESTINE.
