POU4F3

Across TCGA patient cohorts, POU4F3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU4F3-associated genes across cancer lineages are MYH11, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with POU4F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU4F3-to-partner and partner-to-POU4F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by POU4F3-low versus POU4F3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F3→partner) and Y-score (partner→POU4F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYH11 →	-1.536	-3.169	.006	.018	3	2
COAD	Cyclin-B1 →	+0.533	+2.467	.024	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.921	+2.604	<.001	.005	3	2
COAD	FASN →	+0.437	+2.467	.010	.011	3	1
COAD	INPP4B →	-0.443	-3.000	.006	.035	3	1
COAD	PCNA →	+0.342	+2.467	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MYH11 by POU4F3 expression — COAD

Explore this box plot interactively →